Uterine microbiome signatures associated with endometriosis (opens in new tab)

Endometriosis is a chronic inflammatory disorder affecting ~ 10% of reproductive-age women, often causing pelvic pain and infertility. Despite its prevalence, diagnosis remains delayed due to non-specific symptoms and lack of reliable non-invasive biomarkers. Emerging evidence implicates the microbiome in disease pathogenesis. We analyzed uterine microbiomes from 266 tissue samples collected during either the proliferative or secretory phase, using 16S rRNA gene sequencing. Genus-level analys...