Evaluation of the chorioallantoic membrane (CAM) assay as a preclinical model for canine osteosarcoma (opens in new tab)

The chorioallantoic membrane (CAM) model is widely used in human oncology to study tumor growth, angiogenesis, invasion and metastasis. Its low cost and fast turnaround time make this a promising model for veterinary oncology research as well. In this study, the potential of using the CAM assay was evaluated as a preclinical patient-derived xenograft (PDX) model for canine osteosarcoma. Three fresh tumor biopsies from one canine patient were grafted onto the CAM of chick embryos at embryonic ...