Bone neoplasia at the site of previous fracture repair in a dog (opens in new tab)

A seven-year-old female spayed crossbreed dog with a history of acute lameness on the left front leg was presented at the Faculty of Veterinary Medicine (Ghent University). An osteosarcoma (OSA) of the humeral diaphysis was diagnosed. The tumor appeared at a site where repeated attempts had previously been made to stabilize a fracture, that had been sustained at a young age. At the time of presentation, no metastases were detected. The dog underwent total limb amputation. Ex vivo tissue sampl...