Today in @Nature, we report MouseMapper: foundation-model AI to map disease perturbations across the entire mouse body cell-by-cell. (opens in new tab)

Today in @Nature, we report MouseMapper: foundation-model AI to map disease perturbations across the entire mouse body cell-by-cell. In obesity, it revealed body-wide inflammation & unexpected facial nerve damage. 🧵👇🔉 led by @Dorie00 & @yingchen733 nature.com/articles/s4158… Many diseases, including obesity, affect multiple organs and body systems simultaneously. But studying these systemic effects at cellular resolution across the whole body has remained a major challenge.Using DISCO tissue ...