CHORD: a framework for cross-species single-cell integration across gene, cell and cell-type levels (opens in new tab)

Quantifying cross-species relationships among cell types from single-cell transcriptomic data can reveal both conserved and divergent patterns of cell-type hierarchies. However, existing cross-species integration methods can be limited in modeling genes beyond orthologs by leveraging cell-type-resolved transcriptional context, or in learning explicit type-level representations. Here we present CHORD, a cross-species integration framework that jointly learns representations of genes, cells and...