A Unified Agent-Enabled Platform for Drug Repurposing across Molecular, Phenotypic, and Clinical Scales (opens in new tab)

Drug repurposing can accelerate therapeutic development, yet existing computational approaches typically rely on a single evidence type and lack validation across biological scales. Here we present LinkD, an integrated framework combining structure-informed latent diffusion modeling for drug-target interaction prediction with entropy-aware selectivity scoring, large-scale cellular phenotype validation, and real-world clinical evidence from population-scale electronic health records (EHRs). Li...