PEACE: Prototype-aware Effector Analysis via Contrastive Embeddings (opens in new tab)

Pathogenic fungi and oomycetes secrete effector proteins that manipulate host defenses and physiology to facilitate infection. However, in a typical secretome, effectors represent only a small fraction of proteins, creating extreme class imbalance and making deep-learning-based effector prediction prone to false positives. Here, we introduce PEACE (Prototype-aware Effector Analysis via Contrastive Embeddings), a lightweight pipeline that integrates ProtTrans (ProtT5) sequence embeddings with ...