Mechanotransduction-Aware Causal Omics on Tissue Scaffolds: A Controlled Mechanochemical Framework for Identifying Disease Genes Beyond Pure Omics Analysis (opens in new tab)

Omics-based disease-gene discovery is typically performed as if molecular states evolve independently of tissue mechanics. Most current pipelines analyze transcriptomic or multimodal molecular data alone and identify abnormal genes using differential expressions, latent trajectories, or association-based recovery under treatment. However, in mechanically active tissues, gene expression is shaped not only by internal regulatory networks but also by mechanotransduction arising from strain, curv...