H2O: A Foundation Model Bridging Histopathology to Spatial Multi-Omics Profiling (opens in new tab)

Spatial omics technologies have revolutionized the molecular profiling of tissues but remain constrained by high costs and limited scalability. While hematoxylin and eosin (H&E) staining is ubiquitous, it lacks molecular specificity. Here, we present H2O, a generalist AI framework that bridges the modality gap between histopathology and spatial multi-omics, enabling the direct inference of spatial transcriptomics (ST) and proteomics (SP) landscapes from routine H&E images. H2O integrates Visi...