Aiki-XP: leakage-controlled multimodal prediction of within-species relative protein expression at pan-bacterial scale (opens in new tab)

Generalizable protein-expression prediction can accelerate protein engineering, inform disease mechanisms, and help optimize heterologous recombinant protein production. Protein expression is governed by many interacting parameters that no single omics view captures. We develop Aiki-XP, a multimodal platform integrating four biological scales (genome, operon, coding sequence, protein) plus biophysical features across 492,026 genes from 385 bacterial species. Aiki-XP predicts within-species re...