EpiRanha: Hunting for Epitope Similarity with a Structure- and Residue-Aware Graph Neural Network (opens in new tab)

Precise epitope recognition underpins the efficacy and safety of therapeutic antibodies, yet existing approaches to epitope similarity scoring rely largely on sequence identity or rigid structural superposition, limiting their ability to robustly assess cross-reactivity and potential off-target interactions. We introduce EpiRanha, a multimodal framework that integrates residue-level ESM-2 sequence embeddings with an E(n)-equivariant graph neural network operating on three-dimensional protein ...