CellPulse: A Foundation Model of Coordinated Gene Dynamics Simulating Viral Infectious Diseases (opens in new tab)

Understanding how cells respond to perturbations like viral infections requires models capturing coordinated gene dynamics. However, current gene expression foundation models are predominantly reliant on single-cell data and static gene expression, limiting their applicability in real clinical scenarios. We present CellPulse, a direction-aware foundation model trained on the Virus Stimulated Atlas (VISTA), a newly curated atlas of over 23 million bulk RNA-sequencing differential expression pr...