Hierarchical Breakdown of RNA Structure Prediction in CASP16: From Reliable Local Features to Speculative Multimer Assembly (opens in new tab)

CASP16 provided a community-wide benchmark to assess RNA structure prediction across monomeric and multimeric assemblies. In this work, we present the performance of our group (LCBio) as a diagnostic case study to examine the structural and methodological limits of current modeling pipelines. While our workflow achieved top-tier results-ranking first in the RNA multimer category and performing competitively for monomers-achieving high atomic precision remains a significant challenge across th...