Geometric Theoretical Framework for Dynamic Protein Mutation Detection Models: Defect Awareness and Pathogenicity Prediction (opens in new tab)

Traditional protein mutation detection and pathogenicity prediction pipelines rely on static single-conformation structural modeling, inherently ignoring conformational flexibility, dynamic ensemble evolution, and the underlying manifold geometry of protein dynamics. This induces systematic detection failures in flexible regions, allosteric sites, and metastable functional domains, yet lacks a rigorous mathematical characterization of such failure mechanisms. In this work, we establish a theo...