Advancing ab initio genome annotation with OrionGeno (opens in new tab)

The rapid expansion of eukaryotic genome sequencing has created an urgent demand for scalable and accurate gene annotation, particularly for large-scale genomic initiatives such as the Earth BioGenome Project (EBP). Existing ab initio methods often struggle with complex gene architectures and exhibit limited cross-lineage generalizability. Moreover, these frameworks typically treat repetitive DNA sequences (repeats) as genomic noise to be pre-masked, leaving the joint modeling of genes and re...