Structure-Guided Biochemical Design of DNA Tweezers As A Dual Target of the Primary Glioblastoma Biomarkers S100A4 and Midkine (opens in new tab)

Glioblastoma multiforme (GBM) is among the most aggressive malignant brain tumors originating from glial cells and characterized by severe infiltration into surrounding brain tissue, rendering early detection difficult with current diagnostic imaging methods. S100A4 has been identified as a biomarker protein associated with glioblastoma invasiveness due to its role in cell motility and tumor metastasis. Similarly, midkine (MDK) poses an optimal biomedical target for identifying GBM invasive p...