Explainable Prototype Booster: Enhancing Latent Representations of Foundation Models for Gene Expression Prediction (opens in new tab)

Spatial transcriptomics (ST) is a cutting-edge technology that measures gene expression while preserving spatial context and generating pathology-grade tissue images. Although ST has enabled numerous discoveries and demonstrated a huge application potential in pathological diagnosis and prognosis, the technology remains time-consuming and costly. The ability to predict gene markers of cancer from histological H&E-stained tissue images can overcome these technological barriers to open new hori...