Differential peripheral immune dynamics underlie therapeutic response to chemotherapy and chemo-immunotherapy in triple-negative breast cancer (opens in new tab)

Triple-negative breast cancer (TNBC) remains the most aggressive breast cancer subtype, with limited treatment options and variable response to immune checkpoint inhibitors. While tumor-infiltrating lymphocytes have been extensively studied, the integration of system-level peripheral immune dynamics with mechanistic immune regulation underlying therapeutic response and resistance remain poorly defined. Here, we integrate systems-level immune state modeling with pathway-level mechanistic infer...