A 37-million-particle dataset from over 250 experiments to accelerate data-driven cryo-EM analysis (opens in new tab)

Cryogenic Electron Microscopy (cryo-EM) has revolutionized structural biology by enabling near-atomic-resolution structure determination of biological macromolecules. Central to cryo-EM analysis are particles, namely 2D projections of biomolecules extracted from micrographs, which serve as the primary input for 3D reconstruction. While data-driven methods have transformed other scientific domains, their impact on cryo-EM remains limited because existing particle datasets are too small, too na...