From Generalist to Specialist: Evolution of PS2 α-integrins and Implications for Drug Targeting (opens in new tab)

Integrins are heterodimeric transmembrane receptors that mediate cell-cell and cell-extracellular matrix interactions and play essential roles in development and disease. Within the PS2 alpha-integrin subfamily, four paralogs (alphaIIb, alpha5, alpha8, and alphaV) share a conserved RGD-binding motif yet exhibit diverse functional specializations. Integrins have been widely targeted therapeutically for various clinical conditions, though achieving subtype specificity remains a major challenge....