MetaUmbra: Statistically Controlled Genome-Level Presence Inference from Metaproteomic Peptides (opens in new tab)

Taxonomic interpretation of metaproteomic peptides remains difficult because many peptide sequences are present in proteins from different organisms, reducing taxonomic specificity. Current peptide-centric workflows can report taxonomic summaries or taxon level confidence scores, but they do not provide formal statistical evidence that a taxon is present in the microbiome. Here we present MetaUmbra, a tool that derives genome-level statistical significance values from identified peptides. Met...