Joint Variable Selection for Omic Biomarkers in Time-to-Event Data (opens in new tab)

The incidence of the vast majority of neurodegenerative, cancer, and metabolic diseases generally increases exponentially with age. In large-scale biobanks, linking time-to-diagnosis information in electronic health records to multiple genomic (``multiomics'') measures has the potential to reveal the genes and biological pathways involved in the disease onset and progression. To date, association testing has commonly been conducted by testing one variable at a time using semiparametric Cox pr...