Fast and Ultra-Capable Protein Design: Advancing the Frontier Through Atomistic SE(3)-Equivariance with Genie 3 (opens in new tab)

Despite the breakneck pace of progress in protein design methodology, frontier problems remain challenging, with leading methods struggling to design high-affinity binders, scaffold multiple functional motifs, or stabilize large multi-domain proteins. Recent research efforts have focused on two areas: improving model reasoning when generating active sites or binding interfaces, and improving concordance between the design process and the in silico oracle used to select promising designs. In a...