An LLM-driven pipeline for proteomics-based detection and structural modeling of post-translational modifications (opens in new tab)

Post-translational modifications (PTMs) on proteins dynamically regulate their functions and subsequently cellular physiology. Significant advances have been made in their detection and modeling: mass spectrometry-based proteomics has become the cornerstone for PTM detection in complex samples, while emerging structure-prediction frameworks enable modeling of PTM-dependent conformational changes. However, the biological significance of many PTMs remains largely unexplored, in part because int...