ORBIT: Orthogonal Rotation for Biological Inter-species Transfer (opens in new tab)

Motivation. Cross-species gene embeddings are central to transferring functional annotations between species. A recent method demonstrated that species-specific STRING (PPI) network embeddings can be aligned across 1322 eukaryotes with autoencoders (FedCoder), but this approach is computationally expensive, depends on careful hyperparameter selection, leaves substantial room for improvement in cross-species retrieval quality, and has not been demonstrated on coexpression networks. Results. We...