SLiMNet: a deep learning model to detect short linear motifs using protein large language model representations and paired inputs (opens in new tab)

Short linear motifs (SLiMs) are short (3-15 amino acids in length) segments within intrinsically disordered regions (IDRs) that mediate transient protein-protein interactions as well as other functions such as stability and subcellular localization. Only a few thousand out of likely hundreds of thousands have been experimentally validated. SLiMs can be detected as conserved regions inside of IDRs using local alignments, though current approaches have limited sensitivity and specificity and ar...