Gene-Modulated Network Diffusion for Improved Modeling of Amyloid-β Spread in Alzheimer's Disease (opens in new tab)

Understanding the pathogenesis of amyloid-{beta} pathology in Alzheimer's Disease (AD) proves to be a challenge. In this work, we expand upon the application of network diffusion models (NDM) to study pathophysiological spread of amyloid-{beta} throughout white matter structural brain networks. We found that the NDM successfully recaptures subpopulation-level spatial patterns (Pearson's R=0.45-0.48, PFDR < 0.01) of amyloid-{beta} deposition in the Alzheimer's Disease Neuroimaging Cohort at a ...