MUSE enables cross-species multi-omics integration that incorporates transcriptional regulatory modules (opens in new tab)

Recent advances in evolutionary biology and biomedical research have promoted comparative analyses of cellular states and developmental processes across species, leading to the development of numerous cross-species alignment methods based on scRNA-seq data. However, alignments relying solely on RNA expression are strongly driven by lineage signals and cell type-specific transcriptional programs. As a result, they are limited in their ability to identify conserved regulatory modules across spe...