Open-Rosalind: Tool-First Biomedical LLM Agents with Process-Aware Benchmarking (opens in new tab)

Large language models are increasingly used as scientific agents, yet the flexibility that benefits general-purpose agents can conflict with the accountability required in biomedical research. We study whether biomedical agents can be organized around auditable constraints rather than unconstrained autonomy. We present Open-Rosalind, a tool-first bio-agent system designed around four operational principles: evidence-grounded outputs, trace completeness, workflow-constrained execution, and exp...