A structural grammar of truncation across the human homodimer landscape (opens in new tab)

Alternative splicing and proteolytic truncation generate tens of thousands of protein isoforms in the human proteome, but the structural consequences for quaternary state, the level at which most signaling, enzymatic and regulatory function operates, have largely been examined one molecule at a time. Leveraging the recent expansion of the AlphaFold Database to predicted human homodimers, we systematically compared 5,168 canonical-versus-truncated homodimer pairs across the human proteome. In ...