A Fractal-Dimension Framework for Quantifying Self-Similarity in Chromatin Folding (opens in new tab)

The three-dimensional folding of DNA is essential for genome function, but its organization remains difficult to summarize quantitatively across genomic scales. Here, we study DNA folding from Hi-C contact data using a network-based notion of fractal dimension. In this representation, genomic loci are treated as nodes, and observed Hi-C contacts define weighted edges, so that frequently interacting loci are closer in the resulting network. We then estimate fractal dimension using two compleme...