Cell Type-informed Characterization of Spatial Niches from Spatial Multimodal and Multi-omics Data (opens in new tab)

Cell niches play critical roles in tissue organization and orchestrate homeostasis, development, and disease progression. Advances in spatial omics technologies now allow diverse molecular and image-derived data to be jointly captured while preserving spatial context, but deciphering cell niches from such spatial multimodal and multi-omics data remains challenging. Existing computational methods are still limited in their flexibility across variable combinations of spatial modalities and omic...