HAIRpred2: Human Host-Specific Prediction of Antibody-Interacting Residues Using Hybrid Physicochemical and Structural Features (opens in new tab)

Prediction of conformational B-cell epitopes is critical for vaccine design, immunotherapy, and antibody engineering. To date, several host-independent computational methods have been developed for predicting antibody-interacting residues in antigen structures. However, it is well established that antigen-antibody (Ag-Ab) interactions vary depending on the host immune system indicating the importance of developing host-specific prediction models. In this study, we present, for the first time,...