PARiS: Probabilistic Assignment and Repartitioning of isomiR Sequences: A data-driven method for denoising isomiR read count data (opens in new tab)

MicroRNAs (miRNAs) are non-coding RNAs, approximately 18 - 24 nucleotides in length, with important gene regulatory functions. In small RNA sequencing (sRNA-seq), observed iso- forms of miRNA, called isomiRs, arise from my biological and technical processes. Alterations in isomiR expression has been linked to a wide variety of human diseases, from cancers to neurological diseases. However, it is difficult to distinguish be- tween technical and biological isomiRs. We present PARiS, an algorith...