Disease-guided functional gene mapping across species reveals translational correspondences beyond sequence orthology (opens in new tab)

Selecting the correct mouse gene to model a human disease phenotype is critical for translational research, yet sequence-based orthology can fail when genes have been lost, duplicated, or functionally rewired between species. Here we present BRIDGE (Biological Rank Integration for Disease Gene Equivalence), a sequence-free framework that identifies functional mouse equivalents of human disease genes. BRIDGE integrates 3.37 million disease-gene associations, biological pathways, and Gene Ontol...