A Comprehensive Benchmarking of Spatial Deconvolution andDomain Detection Methods across Diverse Tissues and SpatialTranscriptomic Technologies (opens in new tab)

Spatial transcriptomic technologies enable high-resolution characterization of gene expression patterns and reconstruction of cellular architecture within tissue contexts. Two key computational problems have emerged for analyzing these datasets: spatial deconvolution, for disentangling cell-type compositions at spatial locations, and spatial domain detection, for identifying spatially coherent regions within a tissue section. Although numerous methods have been developed for each task, a comp...