Predicting Biological Age and Clinical Biomarkers from DNA Methylation Profiles of Cheek Mucosa (opens in new tab)

Background DNA methylation-based biomarkers have been widely used to predict biological age; however, most blood-derived data have been used in most existing models, and whether cheek mucosa can serve as an alternative indicator for methylation-based estimation of aging-related and clinical phenotypes is unclear. Methods DNA methylation profiles from cheek mucosa and whole blood of 186 Japanese adults were analyzed using Illumina Infinium Methylation Screening Array (MSA). Models were constru...