HESTIA: Scalable Multimodal Integration of Histology and High-Resolution Spatial Transcriptomics for Robust Spatial Domain Identification (opens in new tab)

Spatial omics has revolutionized molecular biology by providing invaluable insights into how native tissue microenvironments regulate cellular functions and disease mechanisms. Accurately capturing this structural complexity and decoding the underlying biological processes requires effectively integrating data from multiple modalities. However, transitioning to subcellular resolutions introduces massive data scales and severe transcriptomic sparsity, which challenge current analytical framewo...