An 8 Gene Bevacizumab Resistance Signature Predicts Prognosis and Reveals Immunosuppressive Microenvironment in Colorectal Cancer (opens in new tab)

Background Bevacizumab resistance severely limits long term efficacy in metastatic colorectal cancer (CRC). This study aimed to develop and validate a bevacizumab resistance associated gene signature for prognosis prediction and immune microenvironment characterization in CRC. Methods Two GEO datasets (GSE19862, GSE86582) with bevacizumab response data and TCGA COAD/READ RNA seq data were analyzed. Overlapping differentially expressed genes (DEGs) linked to both CRC progression and bevacizuma...