Deciphering interaction syntax via decoupling intrinsic lineages and niche pressure (opens in new tab)

Spatial transcriptomics enables the mapping of gene expression within intact tissues, yet a fundamental gap remains between knowing where cells are and understanding how they interact. A cell's measured transcriptome reflects both its intrinsic lineage identity and niche pressure. Here we introduce TRINUS, a self-supervised model that deciphers interaction syntax by generative decoupling of a cell's intrinsic lineage identity from the extrinsic niche pressure. TRINUS maintains a library of co...