Transcriptomics of cold stress and recovery reveal strongly tissue-specific responses (opens in new tab)

Cellular stress responses are often characterized as conserved, cell-autonomous processes. However, it remains unclear whether stress responses are coordinated uniformly across tissues within complex organisms, particularly during ecologically relevant conditions. We investigated tissue- and stage-specific transcriptional responses to cold stress in Drosophila melanogaster. Adults and larvae were independently exposed to a gradual cooling and recovery time series, and three adult tissues (gut...