ProtmRNA: Cross-Modal Knowledge Transfer from Proteins to Messenger RNA (opens in new tab)

Motivation According to the central dogma of molecular biology, messenger RNA (mRNA) sequences are directly translated into amino acid sequences, positioning mRNA as the fundamental intermediary between genetic information and functional proteins. This natural correspondence suggests that mRNA sequence analysis could greatly benefit from the rich evolutionary and functional representations learned by large-scale protein language models. Results ProtmRNA repurposes the pre-trained ESM-2 protei...