Spectral Prompting: Unsupervised Recovery of Human Hair Follicle Cell-Type and Multiscale Systems Architecture from Bulk and Single-Cell RNA-Seq Datasets via Si... (opens in new tab)

Bulk RNA sequencing datasets are assumed to carry minimal resolvable programmatic and cell type biological information; as such, in the absence of single-cell resolution, researchers prioritise data analysis approaches based on differential expression, or rely on deconvolution and co-expression methods that require external reference panels, large multi-sample cohorts, or prior single-cell data to resolve cell-type structure. Here I describe the recovery of specialised cell-type and systems g...