Large-Scale Assessment of Animal-to-Human Drug Translation Using Natural Language Processing (opens in new tab)

Background: Large-scale estimates of animal-to-human drug translation and the study characteristics associated with successful translation remain limited. The expanding preclinical literature also challenges manual evidence synthesis. We developed a natural language processing (NLP) pipeline to structure and link preclinical and clinical evidence at scale. Methods: In this retrospective meta-research study, we analysed more than 500,000 neuroscience-related animal drug studies from PubMed and...