ZipStrain Enables Rapid and Precise Strain-Resolved Metagenomics (opens in new tab)

Strain-resolved metagenomics characterizes microbial communities at nucleotide-level resolution, enabling researchers to differentiate identical from closely related organisms and characterize population structure and gene content variation. Here we introduce ZipStrain, a program that performs highly accurate strain-resolved metagenomics over 500 times faster than available methods while offering superior RAM management. Applied to a dataset of 2,754 samples spanning human populations, we ide...