Atlas-Level Single-Cell and Spatial Transcriptomics Data Integration via PRIME (opens in new tab)

Single-cell RNA sequencing (scRNA-seq) and spatial transcriptomics (ST) have enabled atlas-scale cellular cartography, with consortium efforts now assembling millions of cells across diverse tissues, donors, and technologies to build comprehensive references for cell identify and disease mechanism, yet the scientific value of these atlases hinges on robust computational integration across heterogeneous data sources. Unlike pairwise batch correction, atlas-level integration must jointly reconc...