Biosynthetic glycan modeling reveals metabolic shifts in disease (opens in new tab)

Glycans are biosynthesized by partly overlapping cascades of enzymatic reactions that can be conceptualized as biosynthetic networks. These networks latently contain reaction rates, substrate specificities, and metabolic states of the underlying cells. Yet extracting this information, across tissues, species, and hundreds of datasets, is challenging with existing methods. Here, we present a new structure-aware algorithm for glycan biosynthetic network construction that is easily scalable to a...