SynFit: Synergistic Contrastive Learning for Multi-Objective Protein Fitness Prediction and Optimization (opens in new tab)

Proteins function through a complex interplay of structural and biochemical properties, and mutations can reshape these properties to generate fitness landscapes spanning multiple functional objectives. A central challenge in protein engineering is the need to simultaneously optimize multiple properties. In biocatalysis, for example, practical enzyme development routinely requires the concurrent optimization of catalytic activity, selectivity, stability, and substrate generality. However, des...