Molecular Characterization of T-Lineage Acute Lymphoblastic Leukemia by an Optimal-Transport Based Multi-Omics Integration Framework (opens in new tab)

T-lineage acute lymphoblastic leukemia (T-ALL) is an aggressive pediatric malignancy characterized by complex heterogeneity across multiple molecular layers. Accurate subtyping is essential for understanding disease mechanisms, risk stratification, and guiding targeted therapeutic strategies. However, current diagnostic approaches are labor-intensive and time-consuming, and existing computational methods are limited by reliance on single-modality data or simple integration strategies. Effecti...