biorxiv.org

ATLAS: a scverse-compatible package for multi-omic single-cell trajectory inference integration (opens in new tab)

Single-cell trajectory inference is widely used to study cellular differentiation and fate decisions, yet most existing approaches rely on transcriptomic information alone, limiting their ability to capture the regulatory processes underlying cell-state transitions. This work presents ATLAS (Advanced Trajectory Learning from multi-omics At Single-cell resolution), a scverse-compatible framework for trajectory inference in paired single-cell RNA-seq and ATAC-seq data. ATLAS integrates transcri...

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